Congaplex is used for short-term support of the immune system.*
Supports healthy immune system function
Provides ingredients with antioxidant activity
Supports the thymus gland
Contains ribonucleic acid, which the body uses to build new cells
Contains a combination of key ingredients from Cataplex® A-C, Thymex®, Calcium Lactate®, and Ribonucleic Acid (RNA)
High in antioxidant vitamin C*
How do the ingredients in Congaplex support the immune system?
Congaplex contains vitamins A and C, calcium, and magnesium to support immune system function.*
Vitamin A plays an important role in a healthy immune system by facilitating the development of type 1 and type 2 helper T cells as well as contributing to the function of both T cells and B cells. 1
Vitamin C enhances the healthy function of the immune system by supporting the maturation of T cells. 2 Additionally, vitamin C stimulates the functions of leukocytes and is important in natural killer (NK) cell activity. 3 Vitamin C supports the maintenance and regeneration of cells. 4
It has been shown that for effective T cell activation as well as T cell-dependent immune system response, it is critical to have both Ca 2+ signaling and the rearrangement of the cytoskeletal components of the cell to support that signaling. 5
Research findings suggest an inverse relationship between magnesium levels and the presence of C-reactive protein in blood. C-reactive protein levels are used by doctors as an indicator of inflammation status in the body. 6
Laboratory research by Standard Process scientists concluded that T lymphocyte cells treated with Congaplex showed statistically significant changes in cytokine levels and an increase in T cell signaling in a dose-dependent manner. 7*
How do the ingredients in Congaplex support the thymus gland?
Congaplex contains Cytosol™ extract from the bovine thymus gland to support the healthy function of human thymus gland. T cells are produced in the thymus gland and are very important for a healthy immune system response. 8*
How is ribonucleic acid (RNA) used to support cells experiencing a challenge
Cells require a steady supply of nucleotides to properly build RNA molecules to perform important functions such as protein synthesis and message delivery in cells.
Research has indicated that it is important to have nucleotides readily available to tissues that are experiencing stress. It is thought that during these times of stress the cells require more raw materials, such as nucleotides, to maintain health. More clinical research in adults is needed to better understand the role of dietary nucleotides and immune system response. 9*
What did the Standard Process research and development team discover when studying Immuplex® and Congaplex?
In a 2009 publication, Standard Process scientists reported that in T cell cultures, Immuplex reduced T cell “discussions” and calmed cell signaling. Congaplex increased T cell signaling in a dose-dependent manner. In the mix of human white blood cells, both supplements reacted similarly, suggesting that with the complexity of multiple immune signals, these supplements act in a far more adaptogenic manner. In other words, these supplements work with the complex immune system response instead of simply upregulating or downregulating cell signals. Cell culture is a very simplified way to study these effects and comes with serious limitations. But it does provide a starting point for future investigation and interesting hypotheses related to the underlying mechanism of action for Congaplex and Immuplex.*
1. Haryanto B, Suksmasari T, Wintergerst E, Maggini S. 2015. Multivitamin Supplementation Supports Immune Function and Ameliorates Conditions Triggered By Reduced Air Quality. Vitam Miner 4:2.
2. Manning J, Mitchell B, et al. 2013. Vitamin C Promotes Maturation of T-Cells. Antiox Redox Signal. 19:2054-2067.
3. Haryanto B, Suksmasari T, Wintergerst E, Maggini S. 2015. Multivitamin Supplementation Supports Immune Function and Ameliorates Conditions Triggered By Reduced Air Quality. Vitam Miner 4:2.
4. Ibid.
5. Joseph N, Reicher B, Barda-Saad M. 2014. The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux. Biochim Biophys Acta. 1838(2):557-68.
6. Nielsen FH. 2010. Magnesium, inflammation, and obesity in chronic disease. Nutrition Reviews® Vol. 68(6):333–340.
7. Hanlon PR, Robbins MG, Scholl C, Barnes DM. 2009. Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes. BMC Complementary and Alternative Medicine. 9:51
8. Gould, R. Supporting the Body with Glandular Extracts. Nutri News 71.
9. Hess JR, Greenberg NA. 2012. The Role of Nucleotides in the Immune and Gastrointestinal Systems: Potential Clinical Applications. Nutrition in Clinical Practice. Vol. 27(2): 281-294.